Epidural clonidine applied as an adjunct to nearby anesthetics has three different mechanisms of action. Initially, the stimulation of alpha-two-receptors during the dorsal horn decreases soreness transmission. Next, clonidine can cause local vasoconstriction that limits vascular removing of neighborhood epidural anesthetics. Could be supplied as monotherapy or as adjunctive https://johnw470rld5.wikienlightenment.com/user