Pentobarbital will minimize the extent or effect of meloxicam by impacting hepatic enzyme CYP2C9/ten metabolism. Small/Importance Not known. Contraindicated (1)pentobarbital will lower the extent or outcome of cobimetinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Steer clear of coadministration. Powerful or reasonable CYP3A inducers could lower cobim... https://samuelu639efg9.wikiconversation.com/user